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The chief bioactive phytochemicals in kava are known as kavalactones.Kavalactones act on the central nervous system to improve cognition, mood, dreaming and sedation.In the central nervous system, GABA is the chief inhibitory neurotransmitter.It blocks neuronal activity in certain brain cells especially those belonging to the sleep centers.The sedative effect of kavalactones derive from their ability to increase GABA-A receptor activity.
Valerian is also used to treat stress, anxiety and tension headaches in traditional medicine.
Therefore, it can produce a calming effect and induce sedation.
However, the GABA content of valerian is unlikely to contribute to the sedative effect of the herb because GABA does not cross the blood-brain barrier.
They are also known for their muscle relaxant, anxiolytic and numbing effects.
Kavalactones improves mood and can reduce depression not by affecting serotonin levels but by increasing dopamine levels and enhancing the activities of noradrenaline.
Studies show that the medicinal effects of kava last long after its ingestion.